A lonely Frankenstein (Christian Bale) travels to 1930s Chicago to ask groundbreaking scientist Dr. Euphronious (five-time Oscar nominee Annette Bening) to create a companion for him. The two revive a murdered young woman and The Bride (Jessie Buckley) is born.

What ensues is beyond what either of them imagined: Murder! Possession! A wild and radical cultural movement! And outlaw lovers in a dark and destructible romance with shades of Bonnie and Clyde.